Boris Karloff performs in one of his specialty roles, in the second of Columbia's "Mad Doctor" series. Nearing the completion of his cure for cancer, Karloff's research requires that he freeze the subjects he is attempting to cure, and administer the medicine while they are in a suspended state. Unfortunately, he is accidentally frozen along with his patients, only to be discovered by another young scientist many years later. Once he and his patients are revived--by hilariously low-tech means--the doctor is distressed to find that his hard-won medical breakthrough has been lost. Desperate to rediscover his cure, he resorts to murdering his thawed-out patients, and spirals further and further into madness.